Response of neural stem cells to ionizing radiation
Vol. 15 No. 4 (2018), Review papers
Vol. 15 No. 4 (2018)

Response of neural stem cells to ionizing radiation

Review papers
https://doi.org/10.21641/los.15.4.115
Published 07-01-2019
Katarzyna Ida Kulcenty
1) Radiobiology Lab, Department of Medical Physics, Greater Poland Cancer Centre 2) Department of Electroradiology, Poznan University of Medical Sciences
https://orcid.org/0000-0001-8400-249X
Joanna Patrycja Wróblewska
Department of Pathology, Poznan University Medical Sciences and Greater Poland Cancer Center, Poznan, Poland
Wiktoria Maria Suchorska
1) Radiobiology Lab, Department of Medical Physics, Greater Poland Cancer Centre 2) Department of Electroradiology, Poznan University of Medical Sciences
PDF (Język Polski)

Keywords

neural stem cells
neurogenesis
radiation therapy

How to Cite

Kulcenty, K. I., Wróblewska, J. P., & Suchorska, W. M. (2019). Response of neural stem cells to ionizing radiation. Letters in Oncology Science, 15(4), 157–160. https://doi.org/10.21641/los.15.4.115
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Abstract

Adult neurons are believed to be in a state of growth arrest. The generation of neurons is complete at the time of birth in most of the brain regions. However neurogenesis is present through life in the dentate gyrus of hippocampus and the lateral ventricles due to the presence of neural stem cells (NSC). This postnatal neurogenesis in hippocampus plays a critical role in cognitive development mainly in learning and memory functions. NSC are self-renewing, multipotent cells that generate the neurons and glia of the nervous system. Due to their high proliferation, NSC are highly sensitive to ionizing radiation. This review describes the current knowledge on impact of ionizing radiation on neural stem cells biology. Widening the knowledge of mechanisms involved in radiation-induced neurotoxicity at the level of NSC may help to overcome in the future the side effects occurring after anti-cancer therapies of the brain and help to protect and maintain neurogenesis.
https://doi.org/10.21641/los.15.4.115
PDF (Język Polski)

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