AbstractInflammatory reaction in human body was first observed and described in ancient history dating as far back as 2700 BCE. During the development of modern pathology and immunology in XIX and XX century researchers started to notice connection between carcinogenesis and inflammation. First reports linking the two phenomenon date back to the first half of XIX century and further research allowed deeper understanding of the role of inflammation in cancer. Current data show, that inflammation is a crucial part of progression of tumour. Carcinogenesis is often initiated by chronic inflammation and infection, like in gastrointestinal cancers. Inflammatory reaction is also observed in microenvironment of the tumour, stimulating proliferation and migration of cancer cells. This review summarises the history of research on inflammation and cancer, from the first observation of the connection between the two phenomenon to the most recent findings.
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