Keywords
cGAS-STING
DNA damage repair
anti-cancer immunity
How to Cite
Abstract
Disruption of DNA damage response mechanisms can lead to replicative and transcriptional stress, accumulation of mutations and cytosolic DNA and even cell death. They can also result in malignant transformation, leading to development of breast, ovarian, colorectal, gastric or pancreatic cancer. Regulation of DNA repair processes, however, has applications in cancer therapy through activation of both the body's innate and adaptive immune response. This paper addresses the cGAS-STING system, which plays a key role in the detection of cytosolic DNA, the use of DNA repair element inhibitors (PARPi) in cancer therapy, and provides an overview of the activation of the anti-cancer response related to repair mechanisms such as homologous recombination.
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