Letters in Oncology Science https://journals.wco.pl/index.php/los <p><em>Letters in Oncology Science</em> is an interdisciplinary quarterly journal of the Oncology Centre of Wielkopolska (Polonia Major) Region, aimed at researchers and practicing specialist physicians engaged in studies in the following areas:</p> <ul> <li class="show"><strong>oncology</strong>,&nbsp;</li> <li class="show"><strong>diagnostics of oncologic diseases</strong>,&nbsp;</li> <li class="show"><strong>planning treatment of oncologic diseases</strong>,&nbsp;</li> <li class="show"><strong>radiotherapy</strong>,&nbsp;</li> <li class="show"><strong>chemotherapy</strong>,&nbsp;</li> <li class="show"><strong>immunotherapy</strong>,&nbsp;</li> <li class="show"><strong>dosimetry</strong>,&nbsp;</li> <li class="show"><strong>nuclear medicine</strong>,&nbsp;</li> <li class="show"><strong>research of cancer biology,</strong></li> <li class="show"><strong>molecular biology of cancer,</strong></li> <li class="show"><strong>oncologic care,</strong></li> <li class="show"><strong>radiobiology,</strong></li> <li class="show"><strong>physiotherapy.</strong></li> </ul> Greater Poland Cancer Centre en-US Letters in Oncology Science 2543-6724 Historia badań nad rolą zapalenia w onkologii https://journals.wco.pl/index.php/los/article/view/157 <p>Inflammatory reaction in human body was first observed and described in ancient history dating as far back as 2700 BCE. During the development of modern pathology and immunology in XIX and XX century researchers started to notice connection between carcinogenesis and inflammation. First reports linking the two phenomenon date back to the first half of XIX century and further research allowed deeper understanding of the role <br> of inflammation in cancer. Current data show, that inflammation is a crucial part of progression of tumour. Carcinogenesis is often initiated by chronic inflammation and infection, like <br> in gastrointestinal cancers. Inflammatory reaction is also observed in microenvironment of the tumour, stimulating proliferation and migration of cancer cells. This review summarises the history of research on inflammation and cancer, from the first observation of the connection between the two phenomenon to the most recent findings.</p> Igor Piotrowski Katarzyna Kulcenty Wiktoria Suchorska Copyright (c) 2019-09-17 2019-09-17 16 3 1 6 10.21641/los.2019.16.3.157 Cancer circulating cells: biology and clinical significance https://journals.wco.pl/index.php/los/article/view/155 <p>In recent years, the so-called a liquid biopsy based on the analysis of the circulating tumor cells (CTCs) and / or DNA fragments (circlating tumor DNA, ctDNA) derived from tumor cells in peripheral blood becoming an interesting field of research. CTCs are cells that have penetrated from the primary tumor into the lumen of blood vessels and are transmitted in the body in the bloodstream. It is believed that these cells are a source of metastatic disease development, and their detection and analysis can be important in predicting the course of cancer development. CTC were first described in 1869 by Thomas Ashworth, who postulated that "these cells present in peripheral blood, identical&nbsp;with tumor cells, may explain the presence of multiple tumors of the same type in one patient ". Recent studies confirm the usefulness of determining the number of cells circulating in cancer as a prognostic tool and marker of disease progression.</p> Wiktoria Suchorska Copyright (c) 2019 Letters in Oncology Science http://creativecommons.org/licenses/by-nd/4.0 2019-09-17 2019-09-17 16 3 7 15 10.21641/los.2019.16.3.155 Randomized Controlled Trials in protontherapy – is this the only way? https://journals.wco.pl/index.php/los/article/view/154 <p>Proton Beam Radiotherapy is an emerging new technology in radiation oncology. The current debate underlines the lack of adequate number of randomized clinical trials (RCTs) to prove its clinical priority. This paper sums up the present state-of-art and disputes with the need of using RCTs in the assessment of protontherapy.</p> Marek Konkol Copyright (c) 2019 Letters in Oncology Science http://creativecommons.org/licenses/by-nd/4.0 2019-09-17 2019-09-17 16 3 16 22 10.21641/los.2019.16.3.154 Radiotherapy of gynaecological cancers in the light of the report of the ESTRO 37 conference https://journals.wco.pl/index.php/los/article/view/141 <p>The aim of this paper is to present &nbsp;the most important trends of radiotherapy of gynaecological cancers, presented during the 37<sup>th</sup> conference of European SocieTy for Radiotherapy and Oncology (ESTRO) in Barcelona in 2018.</p> Michał Płachta Copyright (c) 2019 Letters in Oncology Science http://creativecommons.org/licenses/by-nd/4.0 2019-09-17 2019-09-17 16 3 23 26 10.21641/los.2019.16.3.141 Weryfikacja planu leczenia, zaawansowane metody obrazowania - perspektywy. Na podstawie prezentacji ustnych podczas konferencji ESTRO 37 w Barcelonie. https://journals.wco.pl/index.php/los/article/view/137 <p>The aim of this paper is to underline the most important aspects of plan selection in daily clinical routine and perspectives of advanced imaging methods that were presented during ESTRO 37 conference in Barcelona.</p> Emilia Bukowicz Copyright (c) 2019 Letters in Oncology Science http://creativecommons.org/licenses/by-nd/4.0 2019-09-17 2019-09-17 16 3 27 30 10.21641/los.2019.16.3.137