Letters in Oncology Science https://journals.wco.pl/los <p><em>Letters in Oncology Science</em> is an interdisciplinary quarterly journal of the Oncology Centre of Wielkopolska (Polonia Major) Region, aimed at researchers and practicing specialist physicians engaged in studies in the following areas:</p> <ul> <li class="show"><strong>oncology</strong>,&nbsp;</li> <li class="show"><strong>diagnostics of oncologic diseases</strong>,&nbsp;</li> <li class="show"><strong>planning treatment of oncologic diseases</strong>,&nbsp;</li> <li class="show"><strong>radiotherapy</strong>,&nbsp;</li> <li class="show"><strong>chemotherapy</strong>,&nbsp;</li> <li class="show"><strong>immunotherapy</strong>,&nbsp;</li> <li class="show"><strong>dosimetry</strong>,&nbsp;</li> <li class="show"><strong>nuclear medicine</strong>,&nbsp;</li> <li class="show"><strong>research of cancer biology,</strong></li> <li class="show"><strong>molecular biology of cancer,</strong></li> <li class="show"><strong>oncologic care,</strong></li> <li class="show"><strong>radiobiology,</strong></li> <li class="show"><strong>physiotherapy.</strong></li> </ul> en-US wiktoria.suchorska@wco.pl (Wiktoria Suchorska) ojs@fimagis.pl (Radosław Lebowski) Tue, 17 Mar 2020 10:03:00 +0100 OJS 3.1.2.4 http://blogs.law.harvard.edu/tech/rss 60 Radiation shielding swing door drive control system for linear accelerator bunkers https://journals.wco.pl/los/article/view/163 <p>The paper aims to describe a functional radiation shielding door control system as designed and manufactured by the National Centre for Nuclear Research in Otwock, Poland. Basic principles and normative references as well as a short historical overview of control approaches are described.</p> Jaroslaw Kurkiewicz, Michal Salwa, Anna Majewska, Leszek Zylka, Andrzej Kuciak Copyright (c) 2020 Letters in Oncology Science http://creativecommons.org/licenses/by-nd/4.0 https://journals.wco.pl/los/article/view/163 Tue, 17 Mar 2020 09:34:47 +0100 The effect of the combination of TGF-β1 and BMP2 with high-density pellet cell culture during chondrogenic differentiation of pluripotent stem cells. https://journals.wco.pl/los/article/view/169 <p><strong>Introduction: </strong>The osteoarthritis is a serious threat for well-developed and ageing countries. Present techniques of treatment of damaged cartilage are not sufficient. Hence, new strategies should be developed. One of the potential sources for the regeneration of cartilage is pluripotent stem cells (PSC).</p> <p><strong>Aim:</strong> The development of an efficient protocol of chondrogenic differentiation using PSC.</p> <p><strong>Material and methods:</strong> The human embryonic stem cell line (BG01V) was used in this study. The chondrogenic differentiation was performed using high-density pellet culture in the presence of TGF-β1 (10 ng/ml) and BMP2 (100 ng/ml). After 21 days gene expression analysis of markers related to chondrogenesis was done. Additionally, the histological staining was performed to detect the deposition of proteoglycans and collagens in differentiated pellet culture.</p> <p><strong>Results: </strong>Obtained pellets exhibited decreased expression of pluripotent markers. The upregulation of mesodermal marker and type II collagen was observed in differentiated pellets in the presence of applied growth factors. The histological analysis revealed mild deposition of proteoglycans and collagens.</p> <p><strong>Conclusion: </strong>The presented approach enables to obtain chondrogenic pellets in their early stages of chondrogenesis.</p> Michał S. Lach Copyright (c) 2020 Letters in Oncology Science http://creativecommons.org/licenses/by-nd/4.0 https://journals.wco.pl/los/article/view/169 Tue, 17 Mar 2020 00:00:00 +0100 Quality control tests of kV-CBCT imaging with Catphan phantom and automated analysis with Artiscan software. https://journals.wco.pl/los/article/view/164 <p>Image Guided Radiotherapy has become a widely accepted and recommended method of treatment in recent years. IGRT allows for very precisely patient positioning before the delivery of the therapeutic beam, increasing the precision of treatment and reducing the dose of radiation deposited in healthy tissue and critical organs. The main purpose of this work was to perform quality control tests of the kV-CBCT imaging system, determinate reference values for all parameters and to develop QA protocols used in daily routine work. All of QA protocols were developed with Artiscan software. Imaging tests have been performed on TrueBeam linear accelerator from Varian Medical System and Catphan 504 phantom, for two acquisition protocols: Head and Pelvis. The following parameters describing image quality were determined during the study: linearity of the Hounsfield Unit scale, high contrast resolution, low contrast resolution, geometric distortion, noise level, homogeneity. The noise level was 2.75% for the Head protocol and 0.85% for the Pelvis protocol, uniformity was 94% and 98%. All calculated Hounsfield Unit values ​​were within the accepted tolerance range. High contrast resolution was 7.70lp/mm for Head and 5.59lp/mm Pelvis scanning protocols. For the Pelvis&nbsp; protocol, a 15mm diameter object during Supra-Slice 1% conditions has been detected in every measurement series. No geometrical distortion of the image was observed. The developed Quality Assurance protocols are used in clinical routine.</p> Hubert Szweda Copyright (c) 2020 Letters in Oncology Science http://creativecommons.org/licenses/by-nd/4.0 https://journals.wco.pl/los/article/view/164 Fri, 20 Mar 2020 12:01:58 +0100 Treatment tolerance of ultrahypofractionated radiotherapy SBRT using Cyberknife platform for prostate cancer https://journals.wco.pl/los/article/view/168 <p>Prostate cancer is the most common cancer among men over 60 years of age. Treatment of prostate cancer includes surgery, hormone therapy or radiotherapy. Radiotherapy is the least invasive treatment, often combined with other methods or is used alone. Ultrahypofractionated stereotactic radiotherapy (SBRT), which was the subject of this study, in the Greater Poland Cancer Center was carried out on the Cyberknife System.</p> <p>Treatment tolerance can be defined as the degree of occurrence of complications after the therapy. If the side effects of treatment are rare, they are weak and do not reduce the patient's quality of life - the tolerance of treatment is good.</p> <p>This study presented the results of tolerance on ultrahypofractionated radiotherapy treatment in patients with prostate cancer treated at the <strong>Radiation</strong> Oncology <strong>Department</strong> I in Greater Poland Cancer. The patients were irradiated on the Cyberknife using the SBRT method with a dose of 7.0 Gy -7.25 Gy, administered 5 times every other day, up to a total dose of 35.0 Gy - 36.25Gy. Assessment of tolerability of therapy was established on the basis of patient-filled surveys of the IPSS completed in the pre-treatment period, after the last fraction, 1 and 24 months after the end of the RT. Average age patients was 69 years, the average PSA score was 9, and the average Gleason score was 6.</p> <p>Based on our results all patients had a worsening of the urinary tract symptoms during the last irradiation fraction and one month after the end of treatment, while at 24 months after RT, this level compared with the pre-treatment outcome. This phenomenon is associated with the occurrence of the typical radiation reaction for radiotherapy. The results of the study confirm good tolerance of SBRT which coincides with the current state of knowledge and suggest that SBRT due to shorter treatment time, equally high efficacy and good tolerance, could in the future replace conventional radiotherapy schedules in treatment of prostate cancer.</p> Aleksandra Mańczak, Piotr Milecki Copyright (c) 2020 Letters in Oncology Science http://creativecommons.org/licenses/by-nd/4.0 https://journals.wco.pl/los/article/view/168 Tue, 17 Mar 2020 09:45:23 +0100 Methods of imaging and planning in radiotherapy - report on selected speeches at the 37th ESTRO meeting in Barcelona https://journals.wco.pl/los/article/view/144 <div class="_aok _7i2m" tabindex="0" aria-label="In order to update the knowledge on the methods of planning and imaging in radiotherapy, selected scientific reports presented at the 37th ESTRO FORUM of the European Society for Radiotherapy &amp; Oncology (ESTRO) conference were analyzed. By implementing a panel of oral presentations for electroradiologists in the field of knowledge on imaging methods, issues related to contouring of critical organs, which will be briefly described in this paper, were raised."><span class="_3oh- _58nk">In order to update the knowledge on the methods of planning and imaging in radiotherapy, selected scientific reports presented at the 37th <span class="__in">ESTRO</span> FORUM of the European Society for Radiotherapy &amp; Oncology (<span class="__in">ESTRO</span>) conference were analyzed. By implementing a panel of oral presentations for electroradiologists in the field of knowledge on imaging methods, issues related to contouring of critical organs, which will be briefly described in this paper, were raised.</span></div> <p>&nbsp;</p> Jagoda Zychowicz Copyright (c) 2020 Letters in Oncology Science http://creativecommons.org/licenses/by-nd/4.0 https://journals.wco.pl/los/article/view/144 Tue, 17 Mar 2020 08:22:34 +0100 Complications of hormonal therapy (ADT - androgen deprivation therapy) and the movement system in patients with prostate cancer https://journals.wco.pl/los/article/view/156 <p>Androgen Deprivation Therapy is the basis for treatment of advanced prostate cancer. The beneficial influence of ADT on treatment results has been documented. In the clinical practice different complications, related to ADT use, have been observed, among which the musculoskeletal evolve dynamically and tend to deteriorate the patient’s quality of life and daily activity. To prevent or minimize the dynamics of development of these complications it is suggested vitamin D and calcium supplementation, and above all to perform physical exercises and modification of dietary habits. In the current study, the influence of ADT on the skeletal and muscular systems, methods of its diagnosis and prophylaxis has been shown.</p> Jolanta Korczak Copyright (c) 2020 Letters in Oncology Science http://creativecommons.org/licenses/by-nd/4.0 https://journals.wco.pl/los/article/view/156 Mon, 16 Mar 2020 00:00:00 +0100 Qaly - measuring clinical effectiveness using EQ-5D-3L questionnaire https://journals.wco.pl/los/article/view/166 <p>Cancer patients’ quality of life (QoL, QOL) is one of the relevant concerns of the oncologists. Among various factors affecting the patients’ QoL, the particularly important seems to be the health-related QoL (HRQoL). HRQoL can be understood as the measurable characteristic, which indicates the patient’s ability to preserve normal lifestyle during and after the therapy. Evaluation of HRQoL is most often based on the Qaly factor calculation, which covers several aspects of a patient’s lifestyle and recalculates them into points, used to obtain the total monetary benefit of the patient’s healthy year of life.</p> Agata Karolina Pietrzak, Karolina Kucnerowicz, Witold Cholewiński, Piotr Martenka, Erwin Strzesak Copyright (c) 2020 Letters in Oncology Science http://creativecommons.org/licenses/by-nd/4.0 https://journals.wco.pl/los/article/view/166 Tue, 17 Mar 2020 09:38:58 +0100 Radiotherapy treatment for prostate cancer based on presentations from the American Society on Therapeutic Radiation Oncology (ASTRO), San Francisco 2014 and the European Society on Radiation Oncology (ESTRO), Turino 2015 https://journals.wco.pl/los/article/view/167 <p><span lang="CS" style="margin: 0px; font-family: 'Cambria','serif'; font-size: 12pt;">Prostate cancer is one of the most frequent diagnosed cancer in men in devoloped countries.<span style="margin: 0px;">&nbsp; </span>So, the crucial point for achiving the best results of therapy is chosing optimal treatment for particular patient. The appriopriate treatment decision process is challenging for all specialists involved in this process such as urologists, radiation oncologists, and clinical oncologists. Prostate cancer treatment with radiotherapy during the scientific conferences such as ASTRO and ESTRO was one of significant part of scientific disscusion regarding reults of the most important clinical studies evaluated the role of radiotherapy. One of the most important conclusion from recently presented trials for intermediate and high-risk prostate cancer patients stated that combined treatment encompassed androgen deprivation therapy and modern high-dose radiotherapy gives the best results in comparison to high-dose or moderate dose radiotherapy alone. Another very important groups of trials concerned the role of dose escalation for patients with prostate cancer and all studies clearly showed that dose escalation is related with significant clinical benefit, but still it is some concerns regarding translation of biochemical gain into overal survival benefit especially when the follow-up period is relatively short.</span></p> Piotr Milecki Copyright (c) 2020 Letters in Oncology Science http://creativecommons.org/licenses/by-nd/4.0 https://journals.wco.pl/los/article/view/167 Tue, 17 Mar 2020 00:00:00 +0100 The utility and limitations of the 18F-FDG PET/CT study in the oesophageal neoplasms diagnosis https://journals.wco.pl/los/article/view/170 <p>Despite the limitations of the positron emission tomography/computed tomography method using radiopharmaceutical <sup>18</sup>F-Fluorodeoxyglucose (<sup>18</sup>F-FDG PET/CT), i.e. non-specific properties of the radiopharmaceutical<sup> 18</sup>F-FDG and high costs and low PET/CT study availability, several authors indicate the <sup>18</sup>F-FDG PET/CT technique as the most useful in detection, staging and planning treatment of the oesophageal malignancies.</p> Agata Karolina Pietrzak, Piotr Martenka, Erwin Strzesak, Katarzyna Pietrasz, Aleksandra Heydrych, Beata Pisarska, Karolina Kucnerowicz, Witold Cholewiński Copyright (c) 2020 Letters in Oncology Science http://creativecommons.org/licenses/by-nd/4.0 https://journals.wco.pl/los/article/view/170 Tue, 17 Mar 2020 09:50:39 +0100 Ocena efektów kosmetycznych radioterapii interwencyjnej (brachyterapii) w świetle doniesień konferencji ESTRO37. https://journals.wco.pl/los/article/view/172 <p>At the turn of April and May 2018 in Barcelona, Spain, another 37th scientific conference of the European Society for Oncological Radiotherapy (ESTRO) took place. In the course of the session, a panel of GEC-ESTRO group on brachytherapy - a method of radiotherapy involving the direct introduction of a radioisotope into the tumor or a tumor bed was presented. This article aims to present the reports on the cosmetic effects of brachytherapy used in patients not only to cure cancer, but also to spare the organs in which it is located.</p> Artur Jan Chyrek Copyright (c) 2020 Letters in Oncology Science http://creativecommons.org/licenses/by-nd/4.0 https://journals.wco.pl/los/article/view/172 Tue, 17 Mar 2020 09:58:03 +0100 Is there a “best” way to manage respiratory motion?; study based on conference presentations at the ASTRO 59 conference, San Diego, USA. https://journals.wco.pl/los/article/view/174 <p>This study aimed to review and presentation of the way to manage the patient’s respiratory motion in radiotherapy. The review based on selected reports and research problems presented during ASTRO 59th Annual Meeting in San Diego.</p> Agnieszka Skrobała Copyright (c) 2020 Letters in Oncology Science http://creativecommons.org/licenses/by-nd/4.0 https://journals.wco.pl/los/article/view/174 Tue, 17 Mar 2020 10:00:42 +0100 Automated planning, knowledge-based planning and other novel developments in radiotherapy treatment planning - how do they work and perform at the ESTRO 36th conference, Vienna, Austria. https://journals.wco.pl/los/article/view/176 <p>The aim of this study was to review and presentation system of automated planning, knowledge-based planning and other novel developments in radiotherapy treatment planning, with the answer on the question; how do these system work and perform.&nbsp; The review was based on selected reports and research problems presented during ESTRO 36th annual conference held in Vienna, Austria.</p> Agnieszka Skrobała Copyright (c) 2020 Letters in Oncology Science http://creativecommons.org/licenses/by-nd/4.0 https://journals.wco.pl/los/article/view/176 Fri, 20 Mar 2020 00:00:00 +0100