Response of neural stem cells to ionizing radiation

Main Article Content

Katarzyna Ida Kulcenty
Joanna Patrycja Wróblewska
Wiktoria Maria Suchorska

Abstract

Adult neurons are believed to be in a state of growth arrest. The generation of neurons is complete at the time of birth in most of the brain regions. However neurogenesis is present through life in the dentate gyrus of hippocampus and the lateral ventricles due to the presence of neural stem cells (NSC). This postnatal neurogenesis in hippocampus plays a critical role in cognitive development mainly in learning and memory functions. NSC are self-renewing, multipotent cells that generate the neurons and glia of the nervous system. Due to their high proliferation, NSC are highly sensitive to ionizing radiation. This review describes the current knowledge on impact of ionizing radiation on neural stem cells biology. Widening the knowledge of mechanisms involved in radiation-induced neurotoxicity at the level of NSC may help to overcome in the future the side effects occurring after anti-cancer therapies of the brain and help to protect and maintain neurogenesis.

Article Details

How to Cite
Kulcenty, K., Wróblewska, J., & Suchorska, W. (2019). Response of neural stem cells to ionizing radiation. Letters in Oncology Science, 15(4), 157-160. https://doi.org/10.21641/los.15.4.115
Section
Review papers

References

1. Rowland, J.H., et al., Cancer survivorship research in Europe and the United States: where have we been, where are we going, and what can we learn from each other? Cancer, 2013. 119 Suppl 11: p. 2094-108.

2. Piotrowski, I., et al., Carcinogenesis Induced by Low-dose Radiation. Radiol Oncol, 2017. 51(4): p. 369-377.

3. Bauman, G.S., et al., A prospective study of short-course radiotherapy in poor prognosis glioblastoma multiforme. Int J Radiat Oncol Biol Phys, 1994. 29(4): p. 835-9.

4. d'Errico, F., et al., In-phantom dosimetry and spectrometry of photoneutrons from an 18 MV linear accelerator. Med Phys, 1998. 25(9): p. 1717-24.

5. Acharya, M.M., et al., Consequences of ionizing radiation-induced damage in human neural stem cells. Free Radic Biol Med, 2010. 49(12): p. 1846-55.

6. Winocur, G., et al., Inhibition of neurogenesis interferes with hippocampus-dependent memory function. Hippocampus, 2006. 16(3): p. 296-304.

7. Monje, M.L., et al., Irradiation induces neural precursor-cell dysfunction. Nat Med, 2002. 8(9): p. 955-62.

8. Raber, J., et al., Radiation-induced cognitive impairments are associated with changes in indicators of hippocampal neurogenesis. Radiat Res, 2004. 162(1): p. 39-47.

9. Mizumatsu, S., et al., Extreme sensitivity of adult neurogenesis to low doses of X-irradiation. Cancer Res, 2003. 63(14): p. 4021-7.

10. Hellstrom, N.A., et al., Differential recovery of neural stem cells in the subventricular zone and dentate gyrus after ionizing radiation. Stem Cells, 2009. 27(3): p. 634-41.

11. Eriksson, P.S., et al., Neurogenesis in the adult human hippocampus. Nat Med, 1998. 4(11): p. 1313-7.

12. Thwaites, D.I. and J. Malicki, Physics and technology in ESTRO and in Radiotherapy and Oncology: past, present and into the 4th dimension. Radiother Oncol, 2011. 100(3): p. 327-32.

13. Peszynska-Piorun, M., J. Malicki, and W. Golusinski, Doses in organs at risk during head and neck radiotherapy using IMRT and 3D-CRT. Radiol Oncol, 2012. 46(4): p. 328-36.

14. The 2007 Recommendations of the International Commission of Radiological Protection. Ann. ICRP, 2007. 37: p. 1-332.

15. Ishida, Y., et al., Dose-response and large relative biological effectiveness of fast neutrons with regard to mouse fetal cerebral neuron apoptosis. J Radiat Res, 2006. 47(1): p. 41-7.

16. Saha, S., et al., Increased apoptosis and DNA double-strand breaks in the embryonic mouse brain in response to very low-dose X-rays but not 50 Hz magnetic fields. J R Soc Interface, 2014. 11(100): p. 20140783.

17. Katsura, M., et al., Effects of Chronic Low-Dose Radiation on Human Neural Progenitor Cells. Sci Rep, 2016. 6: p. 20027.

18. Kadhim, M., et al., Non-targeted effects of ionising radiation--implications for low dose risk. Mutat Res, 2013. 752(2): p. 84-98.

19. Ivanov, V.N. and T.K. Hei, Radiation-induced glioblastoma signaling cascade regulates viability, apoptosis and differentiation of neural stem cells (NSC). Apoptosis, 2014. 19(12): p. 1736-54.

20. Ivanov, V.N. and T.K. Hei, A role for TRAIL/TRAIL-R2 in radiation-induced apoptosis and radiation-induced bystander response of human neural stem cells. Apoptosis, 2014. 19(3): p. 399-413.