Keywords
nowotwór
leczenie nowotworów
How to Cite
Abstract
Nowotwory nadal stanowią jedną z głównych przyczyn śmiertelności w populacji światowej, a długotrwałe ich leczenie jest trudne i wysoce problematyczne, pomimo znacznego pogłębienia wiedzy z zakresu ich biologii. Obecnie wykorzystywane metody terapeutyczne cechują się wysoką toksycznością, tym samym często udaremniając skuteczne wyleczenie i pogarszając jakość życia chorych. Z tego względu wzrasta zainteresowane środkami, które mogłyby wzmocnić skuteczność konwencjonalnej terapii lub ograniczyć występowanie poważnych skutków ubocznych. Przykładem takiej substancji jest fukoidyna - sulfonowany fukan pochodzenia naturalnego, pozyskiwany z alg i brunatnic. Istnieją liczne doniesienia potwierdzające jej efekty terapeutyczne obejmujące właściwości przeciwnowotworowe, przeciwwirusowe oraz immunomodulujące. Poniższa praca zawiera opis efektów terapeutycznych wywoływanych przez fukoidynę wyekstrahowaną z różnych gatunków alg w poszczególnych modelach nowotworów. Praca uwzględnia poznane dotychczas i proponowane mechanizmy indukcji efektów przeciwnowotworowych oraz krytyczną ocenę ograniczeń fukoidyny jako potencjalnego środka wspomagającego w terapii onkologicznej.
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