Słowa kluczowe
cGAS-STING
naprawa uszkodzeń DNA
odporność przeciwnowotworowa
Jak cytować
Abstrakt
Zaburzenia mechanizmów odpowiedzi na uszkodzenia DNA mogą prowadzić do replikacyjnego i transkrypcyjnego stresu, nagromadzenia mutacji oraz cytozolowego DNA a nawet śmierci komórki. Mogą skutkować również transformacją nowotworową, prowadzącą do rozwoju m.in. raka piersi, jajnika, jelita grubego, żołądka czy trzustki. Regulacja procesów naprawy DNA znajduje jednak zastosowanie w terapii onkologicznej dzięki aktywacji zarówno wrodzonej, jak i adaptacyjnej odpowiedzi immunologicznej organizmu. Niniejsza praca porusza temat systemu cGAS-STING, który pełni kluczową rolę w wykrywaniu cytozolowego DNA, zastosowania inhibitorów elementów naprawy DNA (PARPi) w terapii onkologicznej oraz przedstawia ogólny zarys aktywacji odpowiedzi przeciwnowotworowej związanej z mechanizmami naprawy takimi jak homologiczna rekombinacja.
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Prawa autorskie (c) 2023 Zeszyty Naukowe Wielkopolskiego Centrum Onkologii